Enantioselective formal synthesis of uleine alkaloids from phenylglycinol-derived bicyclic lactams.
نویسندگان
چکیده
A two-step route for the enantioselective construction of the tetracyclic ring system of uleine alkaloids, involving the stereoselective conjugate addition of an appropriate indole-containing nucleophile to a chiral bicyclic delta-lactam and the subsequent cyclization on the indole 3-position of the resulting 4,5-disubstituted 2-piperidone, has culminated in the formal total synthesis of several alkaloids of this group.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 14 شماره
صفحات -
تاریخ انتشار 2004